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Poor Oral Health Cost Your Groups Billions in Productivity

    • Antibacterial compounds from Glycyrrhiza uralensis

      From the Journal of Natural Products Glycyrrhiza uralensis, widely recognized as Chinese licorice, has been used in traditional medicine and naturopathy for thousands of years. In this study, several compounds isolated from G. uralensis were tested against Streptococcus mutans, a bacteria largely responsible for tooth decay. The study found that Glycyrrhizol A showed antibacterial properties against S. mutans, while Glycyrrihol B and isoflavanoid gancaonin G also showed moderate antibacterial results. Download Study  
    • Effectiveness of a Novel Delivery System on Salivary Flow Rate, Quality of Life, and Inhibition of Caries Microbiota in Sjögren's Syndrome Patients

      Sjögren's Syndrome is an auto immune disease, marked by an occurrence of dry mouth and lack of saliva production. Patients with Sjögren's Syndrome were recruited, and instructed to consume two lollipops a day. Some contained xylitol, some contained licorice root extract, and some contained an artificial sweetener. The study has so far found that patients who used the lollipops increased saliva production even after the 10-day course, and some patients showed a lowered bacterial count. Download Study  
    • Effects of herbal lollipops on Streptococcus Mutans levels, Lactobacilli levels and the dental caries experience of children with asthma taking beta2‐adrenergic drugs

      The objective of this study was to determine how effective the six‐month regimen of herbal lollipops is at controlling the Streptococcus Mutans levels, Lactobacilli levels, and the caries process in the study group. This study showed evidence that the herbal lollipops decrease bacterial levels in the oral cavity. A decrease in bacteria, aids in decreasing the caries process, which most children using a beta2-°©-adrenergic agonist would benefit from. Download Study
    • Can a Licorice Lollipop Decrease Cariogenic Bacteria in Nursing Home Residents?

      This population is particularly vulnerable to dental caries due to physical and mental limitations. Eight senior citizens were given at least one lollipop with licorice root extract per day for 21 days. Saliva samples were taken periodically throughout the study. In the end, the participants who consumed the lollipops more consistently had lower levels of Streptococcus mutans than the participants who occasionally missed a day. Those who consistently consumed two per day had even lower levels of S. mutans bacteria. Download Study
    • Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study

      Pre-schoolers aged 2-5 years were given a lollipop with an active ingredient of Glycyrrhiza uralensis each morning and afternoon for three weeks. Of the 66 students who participated fully in the study, 12 were low-risk for future caries risk, 37 were moderate-risk and 17 were high-risk. The study found that high-risk children had a significantly reduced population of Streptococcus mutans, that continued for 22 days after the three-week course of lollipops were administered. Download Study

Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study

M.C. Peters*, J.A. Tallman***, T.M. Braun**, J.J. Jacobson***


AIM: To determine the clinical effect of a simple herbal caries-prevention protocol aimed at reduction of Streptococcus mutans (SM) in young children in a pre-school setting.

STUDY DESIGN: Proof-of-principle pilot study.

METHODS: To prove the concept this pilot study delivered a clinical intervention using sugar-free lollipops containing liquorice root extract. Regimen: Supervised herbal lollipops, twice daily for 3 weeks. Species-specific monoclonal antibody testing of saliva provided SM counts. Children were grouped in high, medium and low caries-risk using baseline SM-levels as risk-indicator. Bacterial numbers at baseline, during intervention, and for 9 weeks post-intervention were compared.

STATISTICS: SM levels were analyzed using GEE modeling.

RESULTS: High-risk children showed the steepest early decrease in mean log-SM (P<. 001). At end of a follow-up period, the log-SM decrease moved the high-risk group down to moderate-risk level. High-risk children showed a decrease in fitted mean SM% not seen in other groups (P<. 001). The decrease reached a nadir around 22-days post-intervention. Twice-daily use of herbal lollipop significantly reduced both number and relative percent of SM in high-risk children. SM numbers were reduced for 22 days after the last lollipop, stabilized and then began to rebound.

CONCLUSION: A potential for simple effective caries-prevention for high-risk children has been demonstrated. Encouraging results warrant randomized clinical trials (RCT) of liquorice root in herbal lollipops or alternative modes of delivery.


Eur Archs Paediatr Dent 2010;11(6):274-278
*School of Dentistry,
**School of Public Health, University of Michigan, Ann Arbor,
***Dental Research and Data Institute, Delta Dental of MI, OH, IN, Okemos, Michigan, USA